WNK4 Enhances the Degradation of NCC through a Sortilin-Mediated Lysosomal Pathway
نویسندگان
چکیده
منابع مشابه
WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.
WNK [with no lysine (K)] kinase is a subfamily of serine/threonine kinases. Mutations in two members of this family (WNK1 and WNK4) cause pseudohypoaldosteronism type II featuring hypertension, hyperkalemia, and metabolic acidosis. WNK1 and WNK4 were shown to regulate sodium chloride cotransporter (NCC) activity through phosphorylating SPAK and OSR1. Previous studies including ours have also sh...
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Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc. A pivotal pathogenic event in prion disease is progressive accumulation of prions, or PrPSc, in brains through constitutive conformational conversion of the cellular prion protein, PrPC, into PrPSc. However, the cellular mechanism by wh...
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Hypertension is a leading cause of morbidity and mortality worldwide, and disordered sodium balance has long been implicated in its pathogenesis. Aldosterone is perhaps the key regulator of sodium balance and thus blood pressure. The sodium chloride cotransporter (NCC) in the distal convoluted tubule of the kidney is a major site of sodium reabsorption and plays a key role in blood pressure reg...
متن کاملThe lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin.
Most soluble lysosomal proteins bind the mannose 6-phosphate receptor (M6P-R) to be sorted to the lysosomes. However, the lysosomes of I-cell disease (ICD) patients, a condition resulting from a mutation in the phosphotransferase that adds mannose 6-phosphate to hydrolases, have near normal levels of several lysosomal proteins, including the sphingolipid activator proteins (SAPs), GM2AP and pro...
متن کاملThe C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway
BACKGROUND Protein degradation is essential for cell homeostasis. Targeting of proteins for degradation is often achieved by specific protein sequences or posttranslational modifications such as ubiquitination. METHODOLOGY/PRINCIPAL FINDINGS By using biochemical and genetic tools we have monitored the localization and degradation of endogenous and chimeric proteins in live primary cells by co...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2009
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2008121275